Francis Ackerman Jr. is one of the most prolific serial killers in US history. But he's not only a serial killer, he's also a serial escapist. When a doctor who has discovered a ground-breaking treatment for psychopaths wants to test his theories upon Ackerman, the madman sees his chance at freedom. The only people that stand in his way are the hospital's head of security and a young woman with a personal vendetta against the killer.